Downstream Process Technology (IB713)


M.Tech (IB)




Programme Core (PC)

Credits (L-T-P): 

04 (3-1-0)


Characteristics of bio-product; stages in Bioseparation; Cell disruption: Homogenizer, bead mill, sonicator. Cell wall permeabilization; Filtration: Filter press, rotary drum filter. Centrifugation: Tubular & disc-stack centrifuges. Extraction: Solvent, Aqueous two-phase, super-critical fluid extraction. Precipitation: solvents, salts. Crystallization. Chromatographic separation and purification processes; membrane technology-Ultra filtration, Dialysis, electro dialysis.


Bioseparations: Downstream Processing by P.A. Belter, E.L. Cussler, and W-S. Hu, Wiley, New York 1988. Separation process in Biotechnology by Juan A. Asenjo, , 1st Edition, CRC 1990 Separation process principles by Seader JD & Henley E.J, 2nd edition,Wiley 2005 Engineering Processes for Bioseparations by Laurence R. Weatherley, Butterworth-Heinemann 1994


Chemical Engineering

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Hari Mahalingam, Associate Professor and Head
Department of Chemical Engineering, NITK, Surathkal
P. O. Srinivasnagar, Mangalore - 575 025
Karnataka, India.

  • Hot line: +91-0824-2474057

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