Downstream Process Technology (CH763)


M.Tech (IBT)




Programme Core (PC)

Credits (L-T-P): 

04 (3-1-0)


Downstream Processing in Biotechnology; Selection of unit operation with due consideration of physical, chemical and biochemical aspect of biomolecules; Basic review of downstream process designing;Cell disruption methods: Mechanical & enzymatic methods;Insoluble removal: Filtration, centrifugation; Extraction: Solvent, aqueous two-phase, supercritical; Precipitation; Crystallization; Membrane separations: Ultra filtration, microfiltration, electro dialysis, Reverse osmosis, pervaporation; Chromatographic separations processes; electrophoretic separations;Quality control and quality assurance in biopharmaceutical industry; Good manufacturing practices.


Separation Process Principles by J. D. Seader& Ernest J. Henley, John Wiley & Sons; 2nd Edition. 2006
Separation processes in Biotechnology by Juan Asenjo,, CRC Press, 1990
Bioseparations Downstream Processing for Biotechnology by Paul A. Belter, E.L. Cussler , Wei-Shou Hu, Wiley India Pvt Ltd. 2011
Biotechnology-Quality assurance and validation by Kenneth E. Avis, Carmen M.Wagner, Vincent L.Wu, CRC Press, 1999.


Chemical Engineering

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Dr. I. Regupathi, Professor and Head
Department of Chemical Engineering, NITK, Surathkal
P. O. Srinivasnagar, Mangalore - 575 025
Karnataka, India.

  • Hot line: +91-0824-2474057

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